Th9 cells in inflammatory bowel diseases.

Abstract

Inflammatory bowel diseases are chronic, relapsing, immunologically mediated disorders of the gastrointestinal tract. Emerging evidence suggests a critical functional role of transcription factors and T cell-related cytokines in ulcerative colitis and Crohn's disease. Gut-residing T cells from patients with inflammatory bowel disease produce high amounts of IL-9. Experimental models of colitis highlighted that IL-9-producing T cells critically interfered with an intact barrier function of the intestinal epithelium by impacting cellular proliferation and tight junction molecules. The blockade of IL-9 was suited to significantly ameliorate the disease activity and severity in experimental models of inflammatory bowel disease thereby suggesting that targeting IL-9 might function as a novel targeted approach for therapy.

• Authors: Benno Weigmann, Markus F Neurath
• Journal: Seminars in immunopathology (Semin Immunopathol) Vol. 39 Issue 1 Pg. 89-95 (01 2017) ISSN: 1863-2300 [Electronic] Germany
• PMID: 27837255 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)

Chemical References

• Cytokines
• Interleukin-9

Topics

• Animals
• Cytokines (genetics, metabolism)
• Disease Models, Animal
• Gene Expression Regulation
• Humans
• Inflammatory Bowel Diseases (etiology, metabolism, pathology)
• Interleukin-9 (genetics, metabolism)
• Intestinal Mucosa (immunology, metabolism, pathology)
• Signal Transduction
• T-Lymphocyte Subsets (immunology, metabolism)
• T-Lymphocytes, Helper-Inducer (immunology, metabolism)