Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in psoriasis in southern Turkey.

Abstract

BACKGROUND::

Psoriasis is a multigenic and multifactorial dermatological disease linked to cardiovascular diseases. Increased levels of homocysteine in patients with psoriasis have been demonstrated in many studies. The most frequently investigated genetic defect that plays a role in homocysteine metabolism is single point substitution (C to T) located on the 677th nucleotide of the methylenetetrahydrofolate reductase gene (MTHFR).

OBJECTIVE::

In this study, we aimed to investigate methylenetetrahydrofolate C677T polymorphism in psoriasis patients in Turkey.

METHODS::

The study included 96 patients with psoriasis and 77 controls from southern Turkey. Methylenetetrahydrofolate C677T polymorphism was analysed using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism methods.

RESULTS::

In the psoriasis group, 34 CC (35.4%), 46 CT (47.9%) and 16 TT (16.7%) genotypes were found, respectively; while in the control group, the figures were 39 (50.6%), 35 (45.5%), 3 (3.9%). Homozygote and heterozygote T alleles of methylenetetrahydrofolate C677T polymorphism were significantly higher in the psoriasis than in the control group (p=0.013).

CONCLUSION::

We firstly found a correlation between methylenetetrahydrofolate C677T polymorphism and psoriasis among the southern Turkish population.

• Authors: Muzeyyen Izmirli, Bilge Bulbul Sen, Eminenur Rifaioglu, Bulent Gogebakan, Ozgur Aldemir, Tuba Sen, Ozlem Ekiz, Davut Alptekin
• Journal: Anais brasileiros de dermatologia (An Bras Dermatol) 2016 Sep-Oct Vol. 91 Issue 5 Pg. 611-613 ISSN: 1806-4841 [Electronic] Spain
• PMID: 27828634 (Publication Type: Journal Article)

Chemical References

• MTHFR protein, human
• Methylenetetrahydrofolate Reductase (NADPH2)

Topics

• Adult
• Female
• Humans
• Male
• Methylenetetrahydrofolate Reductase (NADPH2) (genetics)
• Middle Aged
• Polymorphism, Genetic (genetics)
• Polymorphism, Restriction Fragment Length (genetics)
• Psoriasis (enzymology, genetics)
• Risk Factors
• Turkey