Effects of Maternal Valium Administration on Fetal MRI Motion Artifact: A Comparison Study at High Altitude.

Abstract

PURPOSE:

Fetal MRI is performed without sedation. In cases of maternal claustrophobia or when reduction of fetal motion is critical, benzodiazepines may help. The purpose of this study was to evaluate the effects of low-dose benzodiazepine on fetal motion MRI and its effect on maternal oxygen levels at higher elevation.

METHODS:

A total of 131 fetal MRI scans performed from March 2012 through December 2013 were studied. Nineteen of the cases were performed following Valium administration. Images were graded with a 5-point Likert scale. Using pulse oximetry, maternal oxygen levels were recorded.

RESULTS:

Results were analyzed for each category combining 3 readers' interpretations. Using a 2-sample t test model, the average imaging scores were better for the control than the Valium group (p = 0.0139). Maternal oxygen levels at different times and positions were compared using independent 2-sample t test between the Valium and control groups showing no change in O2 saturation, except when controlling for altitude and gestational age (p = 0.0326).

CONCLUSION:

Administration of low-dose Valium did not decrease fetal motion on MRI. Valium did not pose any risk of maternal hypoxemia, except when controlling for altitude and gestational age on supine position. Thus, caution should be exercised to prevent the risk of fetal hypoxemia.

• Authors: Mariana L Meyers, David M Mirsky, Kimberly A Dannull, Suhong Tong, Timothy M Crombleholme
• Journal: Fetal diagnosis and therapy (Fetal Diagn Ther) Vol. 42 Issue 2 Pg. 124-129 ( 2017) ISSN: 1421-9964 [Electronic] Switzerland
• PMID: 27798935 (Publication Type: Journal Article)
• Copyright: © 2016 S. Karger AG, Basel.

Chemical References

• Anti-Anxiety Agents
• Diazepam

Topics

• Anti-Anxiety Agents (administration & dosage, therapeutic use)
• Anxiety (drug therapy)
• Diazepam (administration & dosage, therapeutic use)
• Female
• Fetal Monitoring
• Fetal Movement (drug effects)
• Humans
• Labor, Obstetric
• Magnetic Resonance Imaging
• Oximetry
• Pregnancy