Malignancies in Children with Human Immunodeficiency Virus Infection - Our Experience at Chandigarh, North India.

Abstract

Background:

With improved survival in children living with human immunodeficiency virus (HIV) infection (CLHIV), malignancies are being increasingly recognized.

Patients and methods:

Among the CLHIV registered at our institute from January 1994 to March 2015, children with malignancy were analysed in detail.

Results:

In total, 734 children affected by HIV were registered. Out of these, 11 children (9 boys, 2 girls) were diagnosed to have malignancy. Malignancy was the presenting feature of HIV infection in 4 children. High-grade non-Hodgkin lymphoma (NHL) was the most common malignancy noted in 9 of 11 (81%) children, whereas the remaining 2 children had Hodgkin's lymphoma. Survival in our cohort was 80% among children in whom chemotherapy was initiated, and overall survival was 36% (4 of 11 children).

Conclusion:

NHL was the most common malignancy in CLHIV in our cohort. Low-conditioning chemotherapy protocols along with initiation of anti-retroviral therapy resulted in improved outcomes in CLHIV with malignancy.

• Authors: Deepti Suri, Sagar Bhattad, Anju Gupta, Amita Trehan, Deepak Bansal, Arvind Rajwanshi, Ashim Das, Amit Rawat, Surjit Singh
• Journal: Journal of tropical pediatrics (J Trop Pediatr) Vol. 63 Issue 3 Pg. 210-216 (06 01 2017) ISSN: 1465-3664 [Electronic] England
• PMID: 27771623 (Publication Type: Journal Article)
• Copyright: © The Author [2016]. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected]

Topics

• Adolescent
• Age Distribution
• Child
• Cohort Studies
• Female
• HIV Infections (complications, diagnosis, epidemiology)
• Humans
• India
• Lymphoma, AIDS-Related (diagnosis, epidemiology, pathology)
• Lymphoma, Non-Hodgkin
• Male
• Medical Records
• Neoplasms (complications, mortality)
• Risk Factors
• Sex Distribution
• Survival Rate