Abstract | OBJECTIVE: MATERIALS AND METHODS: In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin- eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application. RESULTS: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ. CONCLUSION:
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Authors | Erli Zhang, Mingquan Li, Jianjun Zhao, Yuxiang Dong, Xueqin Yang, Jingbo Huang |
Journal | Neuropsychiatric disease and treatment
(Neuropsychiatr Dis Treat)
Vol. 12
Pg. 2481-2487
( 2016)
ISSN: 1176-6328 [Print] New Zealand |
PMID | 27729792
(Publication Type: Journal Article)
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