Prognostic Significance of Neutrophil to Lymphocyte Ratio in Oncologic Outcomes of Cholangiocarcinoma: A Meta-analysis.

Abstract

Increasing evidence indicates that the neutrophil to lymphocyte ratio (NLR) is a useful biomarker of long-term outcomes in patients with cholangiocarcinoma. However, the prognostic role of NLR in patients with cholangiocarcinoma remains unclear. Thus, the current meta-analysis was undertaken to clarify the correlation between NLR and overall survival (OS) in cholangiocarcinoma, and a comprehensive literature research was conducted to understand the association of NLR and prognosis of cholangiocarcinoma. The hazard ratio (HR) with 95% confidence interval (CI) was used to assess OS. The synthesized HR of 1.449 (95% CI: 1.296-1.619, P < 0.001) indicated that a high NLR had an unfavourable effect on OS. Overall, this meta-analysis suggested that elevated preoperative NLR is associated with poorer rates of survival in cholangiocarcinoma patients.

• Authors: De-Wen Tan, Yan Fu, Qi Su, Ming-Jun Guan, Po Kong, Sheng-Qiang Wang, He-Ling Wang
• Journal: Scientific reports (Sci Rep) Vol. 6 Pg. 33789 (10 03 2016) ISSN: 2045-2322 [Electronic] England
• PMID: 27694951 (Publication Type: Journal Article, Meta-Analysis, Review)

Chemical References

• Biomarkers, Tumor

Topics

• Bile Duct Neoplasms (blood, mortality)
• Biomarkers, Tumor (blood)
• Cholangiocarcinoma (blood, mortality)
• Disease-Free Survival
• Female
• Humans
• Lymphocyte Count
• Lymphocytes
• Male
• Neutrophils
• Survival Rate