Abstract | PURPOSE: The aim was to determine the dose-specific incidence and predictors of seed loss/migration after permanent seed implantation (PI) for localized prostate cancer. MATERIALS AND METHODS: The records of 79 patients with T1c-T3a prostate cancer who underwent prostate brachytherapy with loose iodine-125 seeds were retrospectively reviewed. Of these patients, 33 with low or intermediate risk underwent PI with the prescribed dose of 160 Gy for the clinical target volume (CTV), and 46 with high risk underwent PI with 110 Gy for the CTV followed by external beam radiotherapy (EBRT) with 45 Gy. Each CTV was defined as a contoured prostate. After PI, the incidence of seed loss/migration was assessed by a series of radiographs. RESULTS: Seed migration occurred in 22 (0.479 %) of 4589 implanted seeds 1 month after implantation. In PI alone, the number of needles (P = 0.081) and the number of seeds (P = 0.071) showed a trend for a difference between those with and without seed loss. In PI + EBRT, there was a significant difference in the discrepancy between the seed numbers calculated by the nomogram and actually implanted (P = 0.032). CONCLUSIONS: It is suggested that the discrepancy in seed numbers might be the predictor for seed migration in PI with 110 Gy.
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Authors | Katsumi Hirose, Masahiko Aoki, Mariko Sato, Hiroyoshi Akimoto, Yasuhiro Hashimoto, Atsushi Imai, Noritaka Kamimura, Hideo Kawaguchi, Yoshiomi Hatayama, Ichitaro Fujioka, Mitsuki Tanaka, Chikara Ohyama, Yoshihiro Takai |
Journal | Japanese journal of radiology
(Jpn J Radiol)
Vol. 34
Issue 11
Pg. 718-723
(Nov 2016)
ISSN: 1867-108X [Electronic] Japan |
PMID | 27631882
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Brachytherapy
(instrumentation)
- Dose-Response Relationship, Radiation
- Foreign-Body Migration
(diagnostic imaging)
- Humans
- Iodine Radioisotopes
(therapeutic use)
- Male
- Middle Aged
- Prostatic Neoplasms
(radiotherapy)
- Radiotherapy Dosage
- Retrospective Studies
- Risk Factors
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