[Frequency of chromosome aberrations induced by mutagens of various functions in cells of the first division at various times of fixation].

Abstract

The dynamics of chromosome aberrations in human lymphocyte culture cells of the 1-st division after exposure in the G0 phase for 1h to functionally different alkylating mutagens - ethyleneimine derivatives (bifunctional phosphamide, threefunctional thiophosphamide, tetrafunctional dipine and pentafunctional photrin) was analysed. The frequency of chromosome aberrations was constant after exposure to "dicentric" mutagens (dipine, photrin) at all times of fixation, while under the action of "monocentric" mutagens (phosphamide, thiophosphamide) this declined significantly with increasing the duration of cultivation. The portion of aberrations of the chromatid remains unaltered in time, in case of both "dicentric" and "monocentric" mutagens, reaching 75% for "monocentric" and 50% for "dicentric" of the total number of chromosome aberrations.

• Authors: A N Chebotarev, N A Chernyshova
• Journal: Genetika (Genetika) Vol. 25 Issue 3 Pg. 548-51 (Mar 1989) ISSN: 0016-6758 [Print] Russia (Federation)
• Vernacular Title: Chastota khromosomnykh aberratsiĭ, indutsirovannykh mutagenami raznoĭ funktsional'nosti, v kletkakh pervogo deleniia na raznykh srokakh fiksatsii.
• PMID: 2759439 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Mutagens

Topics

• Chromosome Aberrations (drug effects)
• Humans
• Interphase (drug effects)
• Mutagens