Immunohistochemical biomarkers in ameloblastomas.

Abstract

Ameloblastoma is an aggressive odontogenic tumour, which is locally invasive and highly recurrent. Studies show that ameloblastoma is a benign odontogenic neoplasia, being relatively rare and occasionally presenting behaviour of malignant lesions. In addition to these particularities, the histological diagnosis of ameloblastoma can be challenging when the tumour shows high rates of mitosis, absence of nuclear pleomorphism, basilar hyperplasia and neural invasion. In order to help in the diagnosis, prognosis and treatment of this neoplasia, some immunohistochemical markers were shown to be associated with tumoural epithelium. The identification of these markers as well as of their association with clinical signs can be useful to elaborate more efficient treatment strategies and to control this pathology, including improvement of the quality of life of patients affected by this neoplasia. This article aims to review some markers associated with specific molecular pathways, bone remodelling, cell proliferation, apoptosis, cell signalling and tumour suppression.

• Authors: Alan Motta do Canto, Juliana Rodrigues Rozatto, Juliana Lucena Schussel, Ronaldo Rodrigues de Freitas, Bengt Hasséus, Paulo Henrique Braz-Silva
• Journal: Acta odontologica Scandinavica (Acta Odontol Scand) Vol. 74 Issue 8 Pg. 585-590 (Nov 2016) ISSN: 1502-3850 [Electronic] England
• PMID: 27571891 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers, Tumor
• Proto-Oncogene Proteins c-mdm2

Topics

• Adult
• Ameloblastoma (metabolism, pathology)
• Apoptosis
• Biomarkers, Tumor (metabolism)
• Cell Proliferation
• Gene Expression
• Humans
• Jaw Neoplasms (metabolism, pathology)
• Proto-Oncogene Proteins c-mdm2 (metabolism)