Nucleophosmin: from structure and function to disease development.

Abstract

Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.

• Authors: Joseph K Box, Nicolas Paquet, Mark N Adams, Didier Boucher, Emma Bolderson, Kenneth J O'Byrne, Derek J Richard
• Journal: BMC molecular biology (BMC Mol Biol) Vol. 17 Issue 1 Pg. 19 (08 24 2016) ISSN: 1471-2199 [Electronic] England
• PMID: 27553022 (Publication Type: Journal Article, Review)

Chemical References

• MAS1 protein, human
• NPM1 protein, human
• Nuclear Proteins
• Proto-Oncogene Mas
• Nucleophosmin

Topics

• Animals
• Apoptosis
• DNA Repair
• Evolution, Molecular
• Genomic Instability
• Humans
• Models, Molecular
• Mutation
• Neoplasms (genetics, metabolism)
• Nuclear Proteins (chemistry, genetics, metabolism)
• Nucleophosmin
• Protein Conformation
• Proto-Oncogene Mas