Abstract | OBJECTIVE: METHODS: We performed a multicenter retrospective study on patients receiving first-line H. pylori eradication therapy between March 2013 and November 2015 with either vonoprazan-based triple therapy or conventional PPI-based triple therapy. RESULTS: A total of 2715 patients aged 63.0 ± 12.1 years (1412 [52.0%] males) were analyzed. Eradication rates were 87.2% (368/422) for vonoprazan-based therapy and 72.4% (1661/2293) for conventional PPI-based therapy (P < 0.01). Among the former group, there were 10 cases of diarrhea, six of nausea/ vomiting, and five of rash, but the rates of these adverse events were similar to those in the conventional PPI group. CONCLUSION:
Vonoprazan-based triple therapy is feasible, and has a higher rate for H. pylori eradication than conventional PPI as a first-line regimen.
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Authors | Satoki Shichijo, Yoshihiro Hirata, Ryota Niikura, Yoku Hayakawa, Atsuo Yamada, Satoshi Mochizuki, Keigo Matsuo, Yoshihiro Isomura, Motoko Seto, Nobumi Suzuki, Hirobumi Suzuki, Shinzo Yamamoto, Takafumi Sugimoto, Tomoya Omae, Makoto Okamoto, Hirotsugu Watabe, Goichi Togo, Noriyuki Takano, Keisuke Fukui, Yuri Ito, Kazuhiko Koike |
Journal | Journal of digestive diseases
(J Dig Dis)
Vol. 17
Issue 10
Pg. 670-675
(Oct 2016)
ISSN: 1751-2980 [Electronic] Australia |
PMID | 27534444
(Publication Type: Clinical Study, Journal Article, Multicenter Study)
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Copyright | © 2016 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd. |
Chemical References |
- 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Proton Pump Inhibitors
- Pyrroles
- Sulfonamides
- Amoxicillin
- Clarithromycin
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Amoxicillin
(therapeutic use)
- Anti-Bacterial Agents
(therapeutic use)
- Anti-Ulcer Agents
(therapeutic use)
- Clarithromycin
(therapeutic use)
- Drug Therapy, Combination
- Feasibility Studies
- Female
- Helicobacter Infections
(diagnosis, drug therapy)
- Helicobacter pylori
(drug effects)
- Humans
- Male
- Middle Aged
- Proton Pump Inhibitors
(adverse effects, therapeutic use)
- Pyrroles
(adverse effects, therapeutic use)
- Retrospective Studies
- Sulfonamides
(adverse effects, therapeutic use)
- Treatment Outcome
- Young Adult
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