Extended Spectrum Beta Lactamase producing Cephalosporin resistant Salmonella Typhi, reported from Rawalpindi, Pakistan.

Abstract

Typhoid is endemic in many parts of southeast Asia. Due to the resistance of the organism to first line of antibiotics (ampicillin, chloramphenicol, cotrimoxazole) as well as to fluoroquinolones, third generation cephalosporins have been in use for the empiric treatment of typhoid for years. However an increasing incidence of Salmonella Typhi is being reported sporadically from various regions. We report a case of typhoid due to Salmonella Typhi which was non-responsive to treatment with a cephalosporin, was found to be multidrug resistant and resistant to ciprofloxacin and third generation cephalosporin as well. The patient was finally treated successfully with intravenous administration of a carbapenem.

• Authors: Tehmina Munir, Munir Lodhi, Jawad Khaliq Ansari, Saadia Andleeb, Mushtaq Ahmed
• Journal: JPMA. The Journal of the Pakistan Medical Association (J Pak Med Assoc) Vol. 66 Issue 8 Pg. 1035-6 (Aug 2016) ISSN: 0030-9982 [Print] Pakistan
• PMID: 27524545 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carbapenems

Topics

• Adolescent
• Carbapenems (therapeutic use)
• Cephalosporin Resistance
• Drug Resistance, Multiple, Bacterial
• Humans
• Male
• Pakistan
• Salmonella typhi
• Typhoid Fever (drug therapy)