Pituitary Non-Functioning Adenoma Disclosed at 18F-Choline PET/CT to Investigate a Prostate Cancer Relapse.

Abstract

We report the incidental finding of a pituitary macroadenoma on an F-choline PET/CT in a patient with recurrent prostate cancer. The pituitary gland was clearly enlarged and intensely FDG avid (SUVmax, 6.6). The diagnosis was confirmed by a subsequent contrast-enhanced MR evaluation, and the macroadenoma was classified as nonfunctioning on the basis of normality of the specific serum hormonal profile. A follow-up F-choline PET/CT scan performed after 6 months revealed stable dimension, and uptake of the pituitary macroadenoma patient deceased 1 month later. At autopsy, intracytoplasmic vesicles containing growth and prolactin hormones were observed at immunohistochemistry.

• Authors: Anna Margherita Maffione, Giovanni Mandoliti, Felice Pasini, Patrick M Colletti, Domenico Rubello
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 41 Issue 10 Pg. e460-1 (Oct 2016) ISSN: 1536-0229 [Electronic] United States
• PMID: 27500509 (Publication Type: Case Reports, Journal Article)

Chemical References

• fluoromethylcholine
• Choline

Topics

• Adenoma (complications, diagnostic imaging)
• Choline (analogs & derivatives)
• Humans
• Incidental Findings
• Male
• Middle Aged
• Pituitary Neoplasms (complications, diagnostic imaging)
• Positron Emission Tomography Computed Tomography
• Prostatic Neoplasms (complications)
• Recurrence