Carnosic acid protects starvation-induced SH-SY5Y cell death through Erk1/2 and Akt pathways, autophagy, and FoxO3a.

Abstract

Carnosic acid (CA) is recognized as a unique neuroprotective compound in the herb rosemary, since it induces expression of antioxidant enzymes including heme oxygenase-1 (HO-1), γ-glutamylcysteine synthase (γ-GCS), and glutathione S-transferase (GST) via activation of nuclear factor erythroid 2-related factor 2 (Nrf2), which is a nuclear transcription factor. In this study, we examined the cytoprotective effects of CA against starvation. We found that CA protected starvation-induced SH-SY5Y cell death by activating Akt and extracellular signal-regulated kinase 1/2 (Erk1/2). Interestingly, CA induced moderate autophagy and dephosphorylation of a transcriptional factor, the forkhead box protein O3a (FoxO3a). These effects of CA play an important role in cytoprotection.

• Authors: Sachi Shibata, Hiroyuki Ishitobi, Shigeru Miyaki, Tomohiro Kawaoka, Tomoko Kayashima, Kiminori Matsubara
• Journal: International journal of food sciences and nutrition (Int J Food Sci Nutr) Vol. 67 Issue 8 Pg. 977-82 (Dec 2016) ISSN: 1465-3478 [Electronic] England
• PMID: 27435046 (Publication Type: Journal Article)

Chemical References

• Abietanes
• FOXO3 protein, human
• Forkhead Box Protein O3
• Neuroprotective Agents
• Proto-Oncogene Proteins c-akt
• salvin

Topics

• Abietanes (pharmacology)
• Autophagy (drug effects)
• Cell Death (drug effects)
• Cell Line, Tumor
• Cytoprotection (drug effects)
• Forkhead Box Protein O3 (metabolism)
• Humans
• MAP Kinase Signaling System (drug effects)
• Neurons (drug effects, metabolism, pathology)
• Neuroprotective Agents (pharmacology)
• Phosphorylation (drug effects)
• Plants, Medicinal (chemistry)
• Proto-Oncogene Proteins c-akt (metabolism)
• Rosmarinus (chemistry)
• Signal Transduction (drug effects)