Involvement of transcription factor Oct-1 in the regulation of JAK-STAT signaling pathway in cells of Burkitt lymphoma.

Abstract

We studied the role of transcription factor Oct-1 in the regulation of expression of genes of the JAK-STAT signaling pathway in the Namalwa Burkitt's lymphoma cell line. Overexpression of Oct-1 isoforms (Oct-1A, Oct-1L, and Oct-1X) causes a decrease in the activity of four genes involved in the JAK-STAT signaling pathway-IFNAR2, STAT1, STAT2, and STAT4. As a result of our research, it was found that genes STAT2 and STAT4 are direct targets for Oct-1 protein.

• Authors: E V Pankratova, A G Stepchenko, I D Krylova, T N Portseva, S G Georgieva
• Journal: Doklady. Biochemistry and biophysics (Dokl Biochem Biophys) Vol. 468 Issue 1 Pg. 229-31 (May 2016) ISSN: 1608-3091 [Electronic] United States
• PMID: 27417729 (Publication Type: Journal Article)

Chemical References

• IFNAR2 protein, human
• Octamer Transcription Factors
• POU2F3 protein, human
• Protein Isoforms
• RNA, Messenger
• STAT1 Transcription Factor
• STAT1 protein, human
• STAT2 Transcription Factor
• STAT2 protein, human
• STAT4 Transcription Factor
• STAT4 protein, human
• Receptor, Interferon alpha-beta

Topics

• Burkitt Lymphoma (metabolism)
• Cell Line, Tumor
• Gene Expression Regulation, Neoplastic
• Humans
• Octamer Transcription Factors (metabolism)
• Protein Isoforms
• RNA, Messenger (metabolism)
• Real-Time Polymerase Chain Reaction
• Receptor, Interferon alpha-beta (metabolism)
• STAT1 Transcription Factor (metabolism)
• STAT2 Transcription Factor (metabolism)
• STAT4 Transcription Factor (metabolism)
• Signal Transduction