An Overview on Predictive Biomarkers of Testicular Germ Cell Tumors.

Abstract

Testicular germ cell tumors (TGCTs) are frequent solid malignant tumors and cause of death in men between 20-40 years of age. Genetic and environmental factors play an important role in the origin and development of TGCTs. Although the majority of TGCTs are responsive to chemotherapy, about 20% of patient presents incomplete response or tumors relapse. In addition, the current treatments cause acute toxicity and several chronic collateral effects, including sterility. The present mini-review collectively summarize the most recent findings on the new discovered molecular biomarkers such as tyrosine kinases, HMGAs, Aurora B kinase, and GPR30 receptor predictive of TGCTs and as emerging new possible molecular targets for therapeutic strategies. J. Cell. Physiol. 232: 276-280, 2017. © 2016 Wiley Periodicals, Inc.

• Authors: Paolo Chieffi
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 232 Issue 2 Pg. 276-280 (Feb 2017) ISSN: 1097-4652 [Electronic] United States
• PMID: 27405110 (Publication Type: Journal Article, Review)
• Copyright: © 2016 Wiley Periodicals, Inc.

Chemical References

• Biomarkers, Tumor
• MicroRNAs
• Protein Kinase Inhibitors

Topics

• Biomarkers, Tumor (metabolism)
• Humans
• Male
• MicroRNAs (genetics, metabolism)
• Molecular Targeted Therapy
• Neoplasms, Germ Cell and Embryonal (diagnosis, drug therapy, enzymology, genetics)
• Protein Kinase Inhibitors (chemistry, therapeutic use)
• Testicular Neoplasms (diagnosis, drug therapy, enzymology, genetics)