Relationship of asymmetric dimethylarginine (ADMA) with extent and functional severity of coronary atherosclerosis.

Abstract

BACKGROUND:

Elevated serum levels of asymmetric dimethylarginine (ADMA) are associated with endothelial dysfunction and atherogenesis. In patients with suspected coronary artery disease (CAD), we assessed the correlation of serum ADMA levels with extent and functional significance of coronary atherosclerosis.

METHODS:

We enrolled 281 patients with suspected CAD undergoing coronary angiogram. Angiographic CAD severity was evaluated by Bogaty score. In patients with angiographic evidence of at least one intermediate coronary stenosis (≥50% diameter stenosis), functional significance was assessed by fractional flow reserve (FFR). Blood samples were collected in all patients prior to coronary angiography for measurement of serum ADMA levels.

RESULTS:

We observed across tertiles of ADMA levels increasingly higher values of both Stenosis Score (2.25±1.70 vs. 2.89±1.99 vs. 2.95±1.82, p=0.016) and Extent Index (0.52±0.32 vs. 0.61±0.39 vs. 0.72±0.47, p=0.003). The association between ADMA levels and Extent Index remained significant after multivariate adjustment (p=0.005). Patients with FFR ≤0.80 in at least one vessel (n=113) had significantly higher ADMA levels compared with patients without functionally significant CAD (0.51 [0.43-0.64] vs. 0.46 [0.39-0.58]μmol/L, p=0.005). Serum ADMA levels were independent predictors of abnormal FFR after adjustment for extent score (odds ratio 7.35, 95% confidence interval 1.05-56.76, p=0.046).

CONCLUSIONS:

Serum ADMA levels are independent predictors of coronary atherosclerosis extent and functional significance of CAD.

• Authors: Fabio Mangiacapra, Micaela Conte, Chiara Demartini, Olivier Muller, Leen Delrue, Karen Dierickx, Germano Di Sciascio, Bruno Trimarco, Bernard De Bruyne, William Wijns, Jozef Bartunek, Emanuele Barbato
• Journal: International journal of cardiology (Int J Cardiol) Vol. 220 Pg. 629-33 (Oct 01 2016) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 27391005 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Biomarkers
• N,N-dimethylarginine
• Arginine

Topics

• Aged
• Aged, 80 and over
• Arginine (analogs & derivatives, blood)
• Biomarkers (blood)
• Coronary Angiography (methods)
• Coronary Artery Disease (blood, diagnostic imaging)
• Female
• Humans
• Male
• Middle Aged
• Severity of Illness Index