Abstract | BACKGROUND: METHODS: Patients scheduled to receive S-1 adjuvant chemotherapy were randomized to the C/T or the control groups. The C/T group received 700 mg cystine and 280 mg theanine orally 1 week before the administration of S-1, which then continued for 5 weeks. Each group received S-1 for 4 weeks. Blood sampling was performed and AEs were evaluated (CTCAE ver. 4.0) before and after the administration of S-1. S-1 was discontinued when AEs ≥ grade 2 occurred. RESULTS: The incidences of AEs of any grade and those over grade 2 were lower in the C/T group than in the controls. The incidence of diarrhea (G ≥ 2) was significantly less (p < 0.05) in the C/T group (3.1 %) than in the controls (25.8 %). The duration and completion rate of the S-1 adjuvant chemotherapy were significantly longer (p < 0.01) and higher (p < 0.01), respectively, in the C/T group (complete ratio: 75.0 %, duration: 24.8 ± 5.8 days) than in the controls (complete ratio: 35.5 %, duration: 20.0 ± 7.7 days). CONCLUSIONS:
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Authors | Takashi Tsuchiya, Hiroshi Honda, Masaya Oikawa, Tetsuya Kakita, Atsushi Oyama, Hidekazu Oishi, Katsuyuki Tochikubo, Takanao Hashimoto, Shigekazu Kurihara, Tetsuro Shibakusa, Takashi Kayahara |
Journal | International journal of clinical oncology
(Int J Clin Oncol)
Vol. 21
Issue 6
Pg. 1085-1090
(Dec 2016)
ISSN: 1437-7772 [Electronic] Japan |
PMID | 27306219
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antimetabolites, Antineoplastic
- Drug Combinations
- Glutamates
- Protective Agents
- S 1 (combination)
- Tegafur
- Cystine
- Oxonic Acid
- theanine
- Glutathione
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Topics |
- Administration, Oral
- Adult
- Aged
- Antimetabolites, Antineoplastic
(administration & dosage, adverse effects)
- Chemotherapy, Adjuvant
(adverse effects, methods)
- Cystine
(administration & dosage)
- Dietary Supplements
- Dose-Response Relationship, Drug
- Drug Combinations
- Drug Monitoring
- Drug-Related Side Effects and Adverse Reactions
(etiology, metabolism)
- Female
- Gastrointestinal Neoplasms
(drug therapy, pathology)
- Glutamates
(administration & dosage)
- Glutathione
(metabolism)
- Humans
- Male
- Middle Aged
- Oxonic Acid
(administration & dosage, adverse effects)
- Protective Agents
(administration & dosage)
- Tegafur
(administration & dosage, adverse effects)
- Treatment Outcome
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