Abstract | SCOPE: METHODS AND RESULTS: In the present study, APP/PS1 mice, an animal model of AD, were administrated for 6 months with 5 mg/kg/day of HT, a comparable level of HT in daily Mediterranean diet. HT improved electroencephalography activity and marginally benefited cognitive behavior of transgenic mice. In addition, HT treatment ameliorated mitochondrial dysfunction, reduced mitochondrial carbonyl protein, enhanced superoxide dismutase 2 expression, reversed the phase 2 enzyme system and reduced the levels of brain inflammatory markers, but had no effect on brain β- amyloid (Aβ) accumulation in APP/PS1 mice. CONCLUSIONS: These results suggest that HT may represent as a functional ingredient in Mediterranean diet in ameliorating AD-involved neuronal impairment via modulating mitochondrial oxidative stress, neuronal inflammation, and apoptosis without affecting APP processing.
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Authors | Yunhua Peng, Chen Hou, Ziqi Yang, Caixia Li, Liyan Jia, Jing Liu, Ying Tang, Le Shi, Yongqin Li, Jiangang Long, Jiankang Liu |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 60
Issue 11
Pg. 2331-2342
(11 2016)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 27287957
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Amyloid beta-Peptides
- 3,4-dihydroxyphenylethanol
- Phenylethyl Alcohol
|
Topics |
- Aging
- Alzheimer Disease
(metabolism)
- Amyloid beta-Peptides
(metabolism)
- Animals
- Brain
(metabolism)
- Cognition
(drug effects)
- Diet, Mediterranean
- Disease Models, Animal
- Mice
- Mice, Transgenic
- Mitochondria
(metabolism)
- Olea
(chemistry)
- Oxidative Stress
- Phenylethyl Alcohol
(analogs & derivatives, pharmacology)
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