Abstract | OBJECTIVE: To compare efficacy of pharmacotherapies for chronic idiopathic constipation (CIC) based on comparisons to placebo using Bayesian network meta-analysis. DATA SOURCES: We conducted searches (inception to May 2015) of MEDLINE, EMBASE, Scopus and Cochrane Central, as well as original data from authors or drug companies for the medications used for CIC. STUDY SELECTION: Phase IIB and phase III randomised, placebo-controlled trials (RCT) of ≥4 weeks' treatment for CIC in adults with Rome II or III criteria for functional constipation; trials included at least one of four end points. DATA EXTRACTION AND SYNTHESIS: Two investigators independently evaluated all full-text articles that met inclusion criteria and extracted data for primary and secondary end points, risk of bias and quality of evidence. OUTCOMES: Primary end points were ≥3 complete spontaneous bowel movements (CSBM)/week and increase over baseline by ≥1 CSBM/week. Secondary end points were change from baseline (Δb) in the number of SBM/week and Δb CSBM/week. RESULTS: CONCLUSIONS: Current drugs for CIC show similar efficacy. Bisacodyl may be superior to prescription medications for Δb in the number of SBM/week in CIC.
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Authors | Alfred D Nelson, Michael Camilleri, Sakkarin Chirapongsathorn, Priya Vijayvargiya, Nelson Valentin, Andrea Shin, Patricia J Erwin, Zhen Wang, M Hassan Murad |
Journal | Gut
(Gut)
Vol. 66
Issue 9
Pg. 1611-1622
(09 2017)
ISSN: 1468-3288 [Electronic] England |
PMID | 27287486
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/. |
Chemical References |
- Azabicyclo Compounds
- Benzofurans
- Citrates
- Gastrointestinal Agents
- Organometallic Compounds
- Picolines
- TD-5108
- prucalopride
- Bisacodyl
- picosulfate sodium
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Topics |
- Azabicyclo Compounds
(administration & dosage, adverse effects)
- Benzofurans
(administration & dosage, adverse effects)
- Bisacodyl
(administration & dosage, adverse effects)
- Chronic Disease
- Citrates
(administration & dosage, adverse effects)
- Constipation
(diagnosis, drug therapy, physiopathology)
- Defecation
(drug effects)
- Drug Monitoring
(methods)
- Gastrointestinal Agents
(administration & dosage, adverse effects)
- Humans
- Organometallic Compounds
(administration & dosage, adverse effects)
- Picolines
(administration & dosage, adverse effects)
- Randomized Controlled Trials as Topic
- Treatment Outcome
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