Abstract | BACKGROUND/OBJECTIVES: METHODS: A review of microbiological data was performed for the most common organisms causing the infection, antibiotics spectrum and minimum inhibitory concentrations (MIC). A search of the physico-chemical properties of antibiotics was performed to calculate the diffusion coefficients. An estimation of the antibiotic concentrations in pancreatic tissue was obtained using a mathematical model. Efficacy factors (EF) were calculated and the stability of the antibiotic solutions were evaluated to optimize the dosing regimen. RESULTS: CONCLUSIONS: Considering obtained results, some solutions are proposed using saline as diluent and 25 °C of temperature during administration. Imipenem has the best theoretical results in empiric local treatment. Linezolid and tigecycline solutions are not recommended.
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Authors | Jaime González-López, Fernando Macías-García, José Lariño-Noia, Juan Enrique Domínguez-Muñoz |
Journal | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
(Pancreatology)
2016 Sep-Oct
Vol. 16
Issue 5
Pg. 719-25
ISSN: 1424-3911 [Electronic] Switzerland |
PMID | 27267056
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 IAP and EPC. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Anti-Bacterial Agents
- Pharmaceutical Solutions
- Imipenem
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Topics |
- Anti-Bacterial Agents
(administration & dosage, pharmacokinetics, therapeutic use)
- Diffusion
- Drug Stability
- Humans
- Imipenem
(administration & dosage, pharmacokinetics, therapeutic use)
- Injections
- Intraabdominal Infections
(drug therapy, etiology, microbiology)
- Pancreas
(metabolism)
- Pancreatitis, Acute Necrotizing
(complications)
- Pharmaceutical Solutions
- Therapeutic Irrigation
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