NAT2 polymorphisms and risk for Parkinson's disease: a systematic review and meta-analysis.

Abstract

INTRODUCTION:

Several studies suggested a possible association between certain polymorphisms in the N-acetyl-transferase 2 (NAT2) gene (which encodes a very important enzyme involved in xenobiotic metabolism) and the risk for Parkinson's disease (PD). As the results of studies on this issue are controversial, we conducted a systematic review and a meta-analysis of eligible studies on this putative association.

AREAS COVERED:

The authors revised the relationship between NAT2 polymorphisms and the risk of developing PD using several databases, and performed a meta-analysis using the software Meta-Disc1.1.1. In addition heterogeneity between studies was analyzed. A description of studies regarding gene-gene interactions and gene-environmental interactions involving NAT2 polymorphisms is also made.

EXPERT OPINION:

Despite several recent meta-analyses showing an association between several polymorphisms in genes related with detoxification mechanisms such as cytochrome P4502D6 (CYP2D6), and glutathione transferases M1 and T1 (GSTM1, and GSTT1), data on NAT2 gene polymorphisms obtained from the current meta-analysis do not support a major association with PD risk, except in Asian populations. However, data from many studies are incomplete and therefore insufficient data exists to draw definitive conclusions. Several studies suggesting gene-gene and gene-environmental factors involving NAT2 gene in PD risk await confirmation.

• Authors: Félix Javier Jiménez-Jiménez, Hortensia Alonso-Navarro, Elena García-Martín, José A G Agúndez
• Journal: Expert opinion on drug metabolism & toxicology (Expert Opin Drug Metab Toxicol) Vol. 12 Issue 8 Pg. 937-46 (Aug 2016) ISSN: 1744-7607 [Electronic] England
• PMID: 27216438 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)

Chemical References

• Arylamine N-Acetyltransferase
• NAT2 protein, human

Topics

• Arylamine N-Acetyltransferase (genetics)
• Asian People (genetics)
• Gene-Environment Interaction
• Genetic Predisposition to Disease
• Humans
• Parkinson Disease (genetics)
• Polymorphism, Genetic
• Risk