Abstract | INTRODUCTION: METHODS: We conducted an observational, cross-sectional study using sera from 305 adults with well-controlled HIV infection and 30 healthy controls. Sera was tested for markers of complement activation (C3a and C5a levels), complement function (CH50 assay), and immunoglobulin levels (IgG1-IgG4) as IgG can activate complement. We evaluated the association of well-controlled HIV infection with C3a, C5a, CH50, IgG1-IgG4, and total IgG levels using both univariate and multivariate analyses, controlling for factors such as age, sex, race, comorbidities (including hepatitis C coinfection), smoking status, and statin use. RESULTS: Well-controlled HIV infection was associated with a 54% increase in complement activation as measured by C3a levels compared with healthy controls (P < 0.0001). Hepatitis C coinfection was associated with a further 52% increase in complement activation, as measured by C3a levels, over HIV alone (P = 0.003). CONCLUSION: These results suggest that complement activation may contribute to a proinflammatory state even in well-controlled HIV infection. Furthermore, hepatitis C virus coinfection may be even more proinflammatory, in complement activation, compared with HIV infection alone.
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Authors | Alexandria E-B Rossheim, Tina D Cunningham, Pamela S Hair, Tushar Shah, Kenji M Cunnion, Stephanie B Troy |
Journal | Journal of acquired immune deficiency syndromes (1999)
(J Acquir Immune Defic Syndr)
Vol. 73
Issue 1
Pg. 20-6
(09 01 2016)
ISSN: 1944-7884 [Electronic] United States |
PMID | 27192377
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
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Chemical References |
- Immunoglobulin G
- Complement System Proteins
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Topics |
- Adult
- Case-Control Studies
- Complement Activation
- Complement System Proteins
(metabolism, physiology)
- Cross-Sectional Studies
- Female
- HIV Infections
(blood, physiopathology)
- Humans
- Immunoglobulin G
(blood)
- Male
- Middle Aged
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