Abstract | INTRODUCTION: HIV-induced changes in cytokine responses to bacteria may influence susceptibility to bacterial infections and the consequent inflammatory response. METHODS: RESULTS: In asymptomatic subjects, HIV infection was associated with reduced interferon-γ, release after stimulation and priming of the pro-inflammatory cytokine response to non-typhoidal Salmonella. In patients with BSI, we found no such priming effect, nor was there evidence for more profound sepsis-induced immunosuppression in BSI patients with HIV co-infection. CONCLUSIONS: These results suggest a complex effect of HIV on leukocyte responses to bacteria. However, in patients with sepsis, leukocyte responses were equally blunted in patients with and without HIV infection.
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Authors | Michaëla A M Huson, Arie J Hoogendijk, Alex F de Vos, Martin P Grobusch, Tom van der Poll |
Journal | Journal of the International AIDS Society
(J Int AIDS Soc)
2016
Vol. 19
Issue 1
Pg. 20759
ISSN: 1758-2652 [Electronic] Switzerland |
PMID | 27189532
(Publication Type: Case Reports)
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