[THE ETIOLOGY AND PATHOGENESIS OF SUCCESSIVE MAKING TEST ON HYPERTRIGLYCERIDEMIA, HYPERCHOLESTEROLEMIIA AND HYPOGLYCEMIA. THE COMMON CHARACTER OF ETIOLOGIC FACTORS OF METABOLIC PANDEMIC AND COMPENSATORY ROLE OF APOC-111].

Abstract

The concepts of atherosclerosis as afatly acids pathology, deficiency syndrome in cells ofpolyene fatty acids were expounded in 1990. The spirits cholesterol and glycerin play integrated physical chemical function in fatly acids' metabolism in transforming polar fatty acids into such non-polar form as ethers cholesterol and triglycerides. The amount of fatty acids transferred by lipoproteins to triglycerides significantly exceeds amount of fatty acids as ethers cholesterol. The triglycerides dominate in cells and ethers cholesterol outside cells. The hypertriglyceridemia is a disorder of transformation in blood of phylogenetically late insulin-dependent palmitic and oleinic lipoproteins of very low density and receptor apoE/B-100-endocytosis by cells of non-ligand lipoproteins of very low density. The hypertriglyceridemia is a disorder of support of cells with energy substrates, problem of cell "energetics", formalton of adenosine triphosphate. It is proposed to evaluate prognostic value of spirits cholesterol in blood plasma only in case of physiological level of triglycerides. The spirits cholesterol never exceeds content of triglycerides however high would be content of spirits cholesterol in blood plasma under family hypercholesterolemia. The increasing of concentration of triglycerides always results in increasing of content of spirits cholesterol and especially spirits cholesterol-lipoprotein of low density. If level of triglycerides and spirits cholesterol is increased normalization of content of triglycerides using diet is to be implemented To evaluate content of spirits cholesterol in blood plasma is rational only under physiological level of triglycerides. Quite often, after decreasing of content of triglycerides content of spirits cholesterol spontaneously decreases by itself. It is supposed that functions of phylogenetic early resident macrophages of intima and late monocytes-macrophages differs. The functional characteristics of second ones under surplus induction by substrate (non-ligand lipoproteins) forms atheromatosis. The increasing of content of apoC-III in blood plasma--test of accumulation of blood of a physiologicpal mitic lipoproteins of low density, compensatory activation of lipolysis of triglycerides in lipoproteins of low density, but not blockade of biological function of trophology, biological reaction of exotrophy.

• Authors: V N Titov
• Journal: Klinicheskaia laboratornaia diagnostika (Klin Lab Diagn) Vol. 61 Issue 1 Pg. 4-12 (Jan 2016) ISSN: 0869-2084 [Print] Russia (Federation)
• PMID: 27183722 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Apolipoprotein C-III
• Blood Glucose
• Cholesterol Esters
• Fatty Acids
• Lipoproteins, HDL
• Lipoproteins, LDL
• Triglycerides

Topics

• Adaptation, Physiological
• Apolipoprotein C-III (blood)
• Atherosclerosis (blood, diagnosis, epidemiology, pathology)
• Blood Glucose (metabolism)
• Cholesterol Esters (blood)
• Fatty Acids (blood)
• Glucose Tolerance Test
• Humans
• Hypercholesterolemia (blood, diagnosis, epidemiology, pathology)
• Hypertriglyceridemia (blood, diagnosis, epidemiology, pathology)
• Hypoglycemia (blood, diagnosis, epidemiology, pathology)
• Insulin Resistance
• Lipoproteins, HDL (blood)
• Lipoproteins, LDL (blood)
• Macrophages (metabolism, pathology)
• Pandemics
• Triglycerides (blood)
• Tunica Intima (metabolism, pathology)