Breast cancer is a highly prevalent disease, accounting for 29% of invasive
cancers in women. Survival from this disease depends on the stage at diagnosis, with patients who are detected earlier having more favourable outcomes. It is because of this that research groups are focusing on the development of a blood-based
biomarker for
breast cancer. Such
biomarkers may facilitate the detection of
breast cancer in its infancy before it has spread beyond the primary site.
MicroRNAs (
miRNAs) have shown immense potential in this setting. These short,
non-coding RNA sequences have been shown to be dysregulated in
breast cancer. Despite showing immense promise,
miRNAs have not been successfully implemented in the clinical setting due to a lack of a standardised approach which has resulted in conflicting results. These challenges may be addressed at least in part through the study of exosomes. The
biomarker potential for exosomes holds huge promise and may revolutionise the way in which we diagnose and manage
breast cancer. These nanovesicles may be isolated from a variety of bodily fluids, including serum, and their
miRNA content has been shown to reflect that of the parent
breast cancer cell. This review will highlight the nomenclature and defining characteristics of exosomes, and current methods of isolation of serum-derived exosomes. Initial promising reports on the potential utility of exosomal
miRNAs to be used as
breast cancer biomarkers will also be addressed.