Prognostic Factors After Definitive Radio(Chemo)Therapy of Locally Advanced Head and Neck Cancer.

Abstract

AIM:

To identify predictors of locoregional control (LRC) and overall survival (OS) after definitive radio(chemo)therapy for squamous cell carcinoma of the head and neck (SCCHN).

PATIENTS AND METHODS:

Two hundred and seventy-five patients were evaluated; 261 patients received radiochemotherapy with 30-40 mg/m(2) of cisplatin weekly, three courses of cisplatin 100 mg/m(2), two courses of cisplatin 5x20 mg/m(2) or two courses of cisplatin 5×20 mg/m(2)plus 5-fluorouracil. Ten characteristics were analyzed: Pre-radiotherapy hemoglobin, T-/N-category, Karnofsky performance-score (KPS), gender, age, chemotherapy type, tumor site, grading and radiation dose.

RESULTS:

On multivariate analyses, hemoglobin 12-14 g/dl (p=0.040), lower T-category (p=0.010), lower N-category (p=0.042) and female gender (p=0.006) were predictive of LRC. Hemoglobin >12 g/dl (p=0.020), lower N-category (p<0.001), KPS ≥80 (p<0.001), female gender (p=0.024) and cisplatin 100 mg/m(2) or 5×20 mg/m(2) (p<0.001) were predictors of improved OS.

CONCLUSION:

Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted.

• Authors: Daniel Seidl, Stefan Janssen, Primoz Strojan, Amira Bajrovic, Steven E Schild, Dirk Rades
• Journal: Anticancer research (Anticancer Res) Vol. 36 Issue 5 Pg. 2523-6 (May 2016) ISSN: 1791-7530 [Electronic] Greece
• PMID: 27127167 (Publication Type: Journal Article)
• Copyright: Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Cisplatin
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Squamous Cell (therapy)
• Chemoradiotherapy
• Cisplatin (administration & dosage)
• Female
• Fluorouracil (administration & dosage)
• Head and Neck Neoplasms (therapy)
• Humans
• Male
• Middle Aged
• Prognosis
• Squamous Cell Carcinoma of Head and Neck
• Survival Rate