Abstract | BACKGROUND: Vitelliform dystrophies are a group of macular degenerative diseases characterized by round yellow lesions in the macula. While often idiopathic, vitelliform dystrophies include inherited maculopathies such as Best disease and some cases of pattern dystrophy. The prevalence of vitelliform dystrophies in the United States has not been reported. This study examined the prevalence of vitelliform dystrophies in Olmsted County, Minnesota. MATERIALS AND METHODS: The Rochester Epidemiology Project database was used to identify all cases of vitelliform or pattern dystrophy in Olmsted County from 1 January 2000-31 December 2014. RESULTS: CONCLUSIONS: Vitelliform dystrophies affect 1 in 5500 individuals in Olmsted County. While the values in this study provide good estimates for the prevalence of Best disease versus adult-onset vitelliform macular dystrophy, the results are limited by dependence on diagnoses made by other ophthalmologists and underutilization of genetic testing. Thus, these diseases should be thought of as at least as prevalent as reported here. As therapies for Best disease and other macular degenerative diseases are quickly becoming a reality, genetic testing should be employed as the gold standard for diagnosis of these diseases.
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Authors | Lauren A Dalvin, Jose S Pulido, Alan D Marmorstein |
Journal | Ophthalmic genetics
(Ophthalmic Genet)
2017 Mar-Apr
Vol. 38
Issue 2
Pg. 143-147
ISSN: 1744-5094 [Electronic] England |
PMID | 27120116
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Adult
- Age Distribution
- Aged
- Aged, 80 and over
- Child
- Electrooculography
- Female
- Fluorescein Angiography
- Humans
- Male
- Middle Aged
- Minnesota
(epidemiology)
- Prevalence
- Sex Distribution
- Tomography, Optical Coherence
- Vitelliform Macular Dystrophy
(epidemiology, genetics)
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