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Multifunctional mesoporous silica nanoparticles modified with tumor-shedable hyaluronic acid as carriers for doxorubicin.

Abstract
In this paper, a CD44-targeted and redox-responsive drug delivery system based on mesoporous silica nanoparticles (MSNs) was synthesized by conjugating tumor-shedable hyaluronic acid (HA) on the surface of MSNs via disulfide bonds. Doxorubicin hydrochloride (DOX·HCl) was physically encapsulated into HA modified MSNs (MSNs/SS/HA@DOX) as a model drug. MSNs/SS/HA@DOX (40nm) had a high drug loading (14.1%) and redox-responsive drug release property. The cellular uptake behaviors of MSNs/SS/HA@DOX by HeLa and LO2 cells were evaluated by confocal laser scanning microscopy (CLSM) and flow cytometry (FCM). MSNs/SS/HA@DOX exhibited higher cellular uptake efficacy via CD44-mediated endocytosis by HeLa cells (CD44 over-expressed cells) than by LO2 cells (CD44 deficient cells). The in vitro cytotoxicity assay demonstrated that MSNs/SS/HA@DOX exhibited higher cytotoxicity to HeLa cells than to LO2 cells. These results indicated that MSNs/SS/HA@DOX might be promising as a multifunctional drug delivery system to improve the anti-tumor efficacy of chemotherapeutic drugs.
AuthorsJing Zhang, Yujie Sun, Baocheng Tian, Keke Li, Lele Wang, Yan Liang, Jingtian Han
JournalColloids and surfaces. B, Biointerfaces (Colloids Surf B Biointerfaces) Vol. 144 Pg. 293-302 (Aug 01 2016) ISSN: 1873-4367 [Electronic] Netherlands
PMID27107383 (Publication Type: Journal Article)
CopyrightCopyright © 2016 Elsevier B.V. All rights reserved.
Chemical References
  • Drug Carriers
  • Silicon Dioxide
  • Doxorubicin
  • Hyaluronic Acid
Topics
  • Cell Death (drug effects)
  • Cell Survival (drug effects)
  • Doxorubicin (pharmacology)
  • Drug Carriers (chemistry)
  • Drug Liberation
  • Endocytosis (drug effects)
  • Flow Cytometry
  • Fluorescence
  • HeLa Cells
  • Humans
  • Hyaluronic Acid (chemistry)
  • Hydrogen-Ion Concentration
  • Inhibitory Concentration 50
  • Nanoparticles (chemistry, ultrastructure)
  • Oxidation-Reduction
  • Porosity
  • Silicon Dioxide (chemistry)
  • Static Electricity

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