Abstract | PURPOSE: METHODS: We examined TRRAP protein expression in 470 breast cancer tissues and normal breast tissues by tissue microarray to study the correlation between TRRAP expression and clinicopathological features. This was analyzed using the chi-square test. Kaplan-Meier survival curves and log-rank tests were applied to analyze the survival status. Cox regression was applied for multivariate analysis of prognosis. RESULTS: The data demonstrated that expression of TRRAP was significantly lower in breast carcinomas (36.6%) than in corresponding normal breast tissues (50.8%). In addition, TRRAP protein levels negatively correlated with tumor size, and indicated poor differentiation, increased nodal involvement, and low p53-positive rates. Analysis of survival revealed that lower TRRAP expression correlated with shorter survival time. Univariate analyses identified TRRAP and progesterone receptor as independent protective factors for breast cancer prognosis. However, Ki-67, tumor size, and nodal involvement appeared to be independent risk factors. CONCLUSION:
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Authors | Ji Wang, Ming Shan, Tong Liu, Qingyu Shi, Zhenbin Zhong, Wei Wei, Da Pang |
Journal | Journal of breast cancer
(J Breast Cancer)
Vol. 19
Issue 1
Pg. 61-7
(Mar 2016)
ISSN: 1738-6756 [Print] Korea (South) |
PMID | 27066097
(Publication Type: Journal Article)
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