MicroRNA-mediated regulation of glutathione and methionine metabolism and its relevance for liver disease.

Abstract

The discovery of the microRNA (miRNA) family of small RNAs as fundamental regulators of post-transcriptional gene expression has fostered research on their importance in every area of biology and clinical medicine. In the particular area of liver metabolism and disease, miRNAs are gaining increasing importance. By focusing on two fundamental hepatic biosynthetic pathways, glutathione and methionine, we review recent advances on the comprehension of the role of miRNAs in liver pathophysiology and more specifically of models of hepatic cholestasis/fibrosis and hepatocellular carcinoma.

• Authors: Shelly C Lu, José M Mato, Cristina Espinosa-Diez, Santiago Lamas
• Journal: Free radical biology & medicine (Free Radic Biol Med) Vol. 100 Pg. 66-72 (11 2016) ISSN: 1873-4596 [Electronic] United States
• PMID: 27033954 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• MicroRNAs
• Methionine
• Glutathione

Topics

• Animals
• Gene Expression Regulation
• Glutathione (metabolism)
• Humans
• Liver Diseases (metabolism, physiopathology)
• Metabolic Networks and Pathways (genetics)
• Methionine (metabolism)
• MicroRNAs