Nanoparticle Targeting of Neutrophils for Improved Cancer Immunotherapy.

Abstract

Cancer immunotherapy using tumor-specific monoclonal antibodies presents a novel approach for cancer treatment. A monoclonal antibody TA99 specific for gp75 antigen of melanoma initiates neutrophil recruitment in tumor responsible for cancer therapy. Here, a strategy is reported for hijacking neutrophils in vivo using nanoparticles (NPs) to deliver therapeutics into tumor. In a mouse model of melanoma, it is shown that systemically delivered albumin NPs increase in tumor when TA99 antibody is injected; and the NP tumor accumulation is mediated by neutrophils. After the administration of pyropheophorbide-a loaded albumin NPs and TA99, photodynamic therapy significantly suppresses the tumor growth and increases mouse survival compared with treatment with the NPs or TA99. The study reveals a new avenue to treat cancer by NP hitchhiking of immune systems to enhance delivery of therapeutics into tumor sites.

• Authors: Dafeng Chu, Qi Zhao, Jian Yu, Faya Zhang, Hui Zhang, Zhenjia Wang
• Journal: Advanced healthcare materials (Adv Healthc Mater) Vol. 5 Issue 9 Pg. 1088-93 (05 2016) ISSN: 2192-2659 [Electronic] Germany
• PMID: 26989887 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antineoplastic Agents, Immunological

Topics

• Animals
• Antineoplastic Agents, Immunological (chemistry, immunology, pharmacology)
• Immunotherapy
• Mice
• Nanoparticles (chemistry, therapeutic use)
• Neoplasms, Experimental (drug therapy, immunology, pathology)
• Neutrophil Infiltration (drug effects, immunology)
• Neutrophils (immunology)