Abstract | BACKGROUND: Preventive chemotherapy with albendazole or mebendazole is the current strategy to control soil-transmitted helminth (STH) infections (i.e. Ascaris lumbricoides, hookworm and Trichuris trichiura). STH reinfections, in particular A. lumbricoides and T. trichiura occur rapidly after treatment with the standard drugs. However, their low efficacy against T. trichiura, made an accurate assessment of reinfection patterns impossible. METHODS: RESULTS: For a total of 405 children complete baseline and follow-up data were available. Similar to the efficacy determined after 3 weeks, 18 weeks after treatment albendazole- oxantel pamoate showed a significantly higher efficacy against T. trichiura (CR: 54.0 %, 95 % CI: 43.7-64.0; ERR: 98.6 %, 95 % CI: 97.8-99.2) compared to the other treatment arms. Children treated with albendazole- oxantel pamoate or albendazole- ivermectin had fewer moderate infections compared to children treated with albendazole. The reinfection rates 18 weeks post-treatment among all treatment arms were 37.2 % for T. trichiura (95 % CI: 28.3-46.8), 34.6 % for A. lumbricoides (95 % CI: 27.3-42.3) and 25.0 % for hookworms (95 % CI: 15.5-36.6). CONCLUSION: TRIAL REGISTRATION: Current Controlled Trials ISRCTN80245406.
|
Authors | Benjamin Speich, Wendelin Moser, Said M Ali, Shaali M Ame, Marco Albonico, Jan Hattendorf, Jennifer Keiser |
Journal | Parasites & vectors
(Parasit Vectors)
Vol. 9
Pg. 123
(Mar 02 2016)
ISSN: 1756-3305 [Electronic] England |
PMID | 26935065
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anthelmintics
- Drug Combinations
|
Topics |
- Adolescent
- Anthelmintics
(administration & dosage)
- Ascariasis
(drug therapy, prevention & control)
- Child
- Drug Combinations
- Female
- Hookworm Infections
(drug therapy, prevention & control)
- Humans
- Male
- Parasite Egg Count
- Recurrence
- Secondary Prevention
- Tanzania
- Treatment Outcome
- Trichuriasis
(drug therapy, prevention & control)
|