Abstract | BACKGROUND: METHODS: Pertinent databases (PubMed, other) were searched for relevant articles published from January 2004 to March 2015. Data collected included ACE incidence, healthcare resource use, costs, change in quality of life attributed to ACEs, and treatment practice for prevention of ACEs in patients with concomitant HF and CAD. RESULTS: Mortality rates for patients with both HF and CAD ranged from 4.9-12.3% at 30 days to 13.7-86% for periods between 9.9 months and 10 years. Incidence of ACEs among HF patients with CAD is, respectively, at least 82% and 15% higher than for patients without HF or without CAD, except for stroke investigated in two studies. All-cause and HF-related hospitalization is the main driver of the economic burden in patients with HF, the majority of whom had CAD origin. Despite high prevalence of ischemic complications, there is limited evidence to support the use of warfarin-type antithrombotics among HF patients. CONCLUSION: This study confirms that patients with concomitant HF and CAD are at elevated risk for ACEs and suggests the need for effective new antithrombotic treatments to further decrease ischemic complication rates in this population.
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Authors | Louis Lavoie, Hanane Khoury, Sharon Welner, Jean-Baptiste Briere |
Journal | Cardiovascular therapeutics
(Cardiovasc Ther)
Vol. 34
Issue 3
Pg. 152-60
(Jun 2016)
ISSN: 1755-5922 [Electronic] England |
PMID | 26915344
(Publication Type: Journal Article, Review)
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Copyright | © 2016 John Wiley & Sons Ltd. |
Chemical References |
- Anticoagulants
- Fibrinolytic Agents
- Platelet Aggregation Inhibitors
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Topics |
- Anticoagulants
(therapeutic use)
- Chronic Disease
- Comorbidity
- Coronary Artery Disease
(economics, epidemiology, mortality, therapy)
- Cost-Benefit Analysis
- Drug Costs
- Fibrinolytic Agents
(therapeutic use)
- Heart Failure
(economics, epidemiology, mortality, therapy)
- Humans
- Incidence
- Myocardial Infarction
(economics, epidemiology, mortality, prevention & control)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Prevalence
- Prognosis
- Risk Factors
- Stroke
(economics, epidemiology, mortality, prevention & control)
- Time Factors
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