Abstract | BACKGROUND & AIMS: METHODS: We collected data from 11,001 patients with IBD receiving care at hospitals in the Greater Boston metropolitan area from 1998 through 2010. Diagnoses of CRC were determined using validated International Classification of Diseases, 9th revision, Clinical Modification codes. Statin use before diagnosis was assessed through analysis of electronic prescriptions. We performed multivariate logistic regression analyses, adjusting for potential confounders including primary sclerosing cholangitis, smoking, increased levels of inflammation markers, and CRC screening practices to identify an independent association between statin use and CRC. We performed sensitivity analyses using propensity score adjustment and variation in the definition of statin use. RESULTS: In our cohort, 1376 of the patients (12.5%) received 1 or more prescriptions for a statin. Patients using statins were more likely to be older, male, white, smokers, and have greater comorbidity than nonusers. Over a follow-up period of 9 years, 2% of statin users developed CRC compared with 3% of nonusers (age-adjusted odds ratio, 0.35; 95% confidence interval, 0.24-0.53). On multivariate analysis, statin use remained independently and inversely associated with CRC (odds ratio, 0.42; 95% confidence interval, 0.28-0.62). Our findings were robust on a variety of sensitivity and subgroup analyses. CONCLUSIONS:
Statin use was associated inversely with the risk of CRC in a large IBD cohort. Prospective studies on the role of statins as chemopreventive agents are warranted.
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Authors | Ashwin N Ananthakrishnan, Andrew Cagan, Tianxi Cai, Vivian S Gainer, Stanley Y Shaw, Susanne Churchill, Elizabeth W Karlson, Shawn N Murphy, Katherine P Liao, Isaac Kohane |
Journal | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
(Clin Gastroenterol Hepatol)
Vol. 14
Issue 7
Pg. 973-9
(07 2016)
ISSN: 1542-7714 [Electronic] United States |
PMID | 26905907
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Adult
- Aged
- Boston
(epidemiology)
- Cohort Studies
- Colorectal Neoplasms
(epidemiology, prevention & control)
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Inflammatory Bowel Diseases
(complications)
- Male
- Middle Aged
- Risk Assessment
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