Abstract | OBJECTIVE: STUDY DESIGN: Five cases of ameloblastic carcinoma (AC), 18 cases of solid ameloblastoma (SA), and seven of unicystic ameloblastoma (UA) were selected. The immunohistochemical expression of MMPs was assessed by the percentage of positive tumor cells and stained stroma. The mean argyrophilic nucleolar organizer region (AgNOR) and the percentage of cells with more than one AgNOR per nucleus were evaluated. RESULTS: Statistically significant higher mean AgNOR was observed in AC than in SA and UA. MMP-2 was expressed similarly in tumor and stroma among groups. MMP-9 was higher in the stroma of SA than that of UA (P = .0484). CONCLUSIONS: The cell proliferation was related to the greater aggressiveness of AC. High expression of MMP-2 and MMP-9 in all lesions highlighted the importance of these enzymes in the biology of ameloblastic tumors.
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Authors | Alessandra Dutra da Silva, Thaíse Gomes E Nóbrega, Annemarie Warstat Saudades, Maria Inês Otero, Chris Krebs Danilevicz, Alessandra Selinger Magnusson, Ana Luisa Saraiva Homem de Carvalho, Pantelis Varvaki Rados, Vinicius Coelho Carrard, Fernanda Visioli, Manoel Sant'Ana Filho |
Journal | Oral surgery, oral medicine, oral pathology and oral radiology
(Oral Surg Oral Med Oral Pathol Oral Radiol)
Vol. 121
Issue 4
Pg. 396-401.e1
(Apr 2016)
ISSN: 2212-4411 [Electronic] United States |
PMID | 26899292
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Ameloblastoma
(enzymology, pathology)
- Biomarkers, Tumor
(metabolism)
- Brazil
- Cell Proliferation
- Child
- Cross-Sectional Studies
- Female
- Humans
- Male
- Mandibular Neoplasms
(enzymology, pathology)
- Matrix Metalloproteinase 2
(metabolism)
- Matrix Metalloproteinase 9
(metabolism)
- Middle Aged
- Retrospective Studies
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