Treatment of duodenal ulcers by antacid (Al-Mg-hydroxy-carbonate). A controlled, randomized, prospective, multicentre clinical trial.

Abstract	TISACID (a new, modern Hungarian Al-containing antacid) with a high acid-neutralizing capacity (greater than 26.8 mmol/g) also enhances gastric mucosal defense mechanisms (prostaglandin-dependent gastroprotection). A simple-blind, prospective, randomized, parallel multicentre clinical trial has been performed on both the clinical efficacy and possible side effects of TISACID monotherapy (Al-Mg-hydroxy-carbonate) on informed patients suffering from active duodenal ulcers. The study groups were as follows: Group "A": 3 g/day of TISACID (acid-neutralizing capacity = 78 mmol, n = 85), Group "B": 6 g/day of TISACID (acid-neutralizing capacity = 156 mmol, n = 88), Group "C": 12 g/day of TISACID (acid-neutralizing capacity = 312 mmol, n = 68), Group "D": (as control): (1.0 g/day cimetidine (HISTODIL, RGH, Budapest, n = 91). The total number of patients: 332. It was found that: 1. The new Hungarian antacid compound (both tablet and suspension) can essentially accelerate the healing rate of duodenal ulcers. 2. The cumulative healing rate of ulcers and the decrease of complaints can be achieved equally by relatively low doses of TISACID monotherapy and cimetidine alone. 3. There were no differences between the clinical potency and side-effects of TISACID tablet and suspension.
Authors	L Nagy, G Nagy, I Rácz, L Simon, I Solt, I Patty, F Tárnok, G Mózsik, T Jávor
Journal	Acta physiologica Hungarica (Acta Physiol Hung) Vol. 73 Issue 2-3 Pg. 331-9 ( 1989) ISSN: 0231-424X [Print] Hungary
PMID	2688360 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References	Antacids Carbonates almagate Aluminum Hydroxide Cimetidine Magnesium Magnesium Hydroxide
Topics	Adolescent Adult Aged Aluminum Hydroxide (adverse effects, therapeutic use) Antacids (adverse effects, therapeutic use) Carbonates (adverse effects, therapeutic use) Cimetidine (therapeutic use) Duodenal Ulcer (drug therapy) Female Humans Magnesium (therapeutic use) Magnesium Hydroxide (adverse effects, therapeutic use) Male Middle Aged Multicenter Studies as Topic Prospective Studies Randomized Controlled Trials as Topic Single-Blind Method

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