Abstract | BACKGROUND: Data on combined hormonal oral contraceptives' (OCs) effects on metabolic changes in women with polycystic ovary syndrome (PCOS) have been conflicting and were predominantly based on OCs with cyproterone acetate (unavailable in the United States) Most studies did not include normal women as controls. We compared metabolic changes before and after an OC commonly used in the United States between women with and without PCOS. METHODS: RESULTS: At baseline, PCOS women had lower insulin sensitivity (Matsuda index p = 0.0093, HOMA-ISI p = 0.0397), higher fasting insulin (p = 0.0495), fasting glucose (p = 0.0393), AUC insulin (p = 0.0023), and triglycerides (p = 0.0044) versus controls. Baseline AUC glucose did not differ between PCOS women and controls. After 3 months of OC use, glucose tolerance worsened in PCOS women versus controls (p = 0.0468). Higher baseline androgens were predictive of worsened glucose tolerance, and a reduction of AUC insulin during OC use. The insulinogenic index significantly decreased in PCOS women (p < 0.01), while fasting insulin and insulin resistance significantly worsened in control women. CONCLUSION: Women with PCOS exhibited worsened glucose tolerance (demonstrated by AUC glucose) after 3 months of a commonly used OC compared with control women. Larger studies with longer follow-up should confirm these findings.
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Authors | Adeola A Adeniji, Paulina A Essah, John E Nestler, Kai I Cheang |
Journal | Journal of women's health (2002)
(J Womens Health (Larchmt))
Vol. 25
Issue 6
Pg. 638-45
(06 2016)
ISSN: 1931-843X [Electronic] United States |
PMID | 26871978
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Carbohydrates
- Contraceptives, Oral
- Contraceptives, Oral, Combined
- Contraceptives, Oral, Hormonal
- Estrogens
- Gonadal Steroid Hormones
- Insulin
- Lipids
- Norgestrel
- Ethinyl Estradiol
- norgestimate
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Topics |
- Adult
- Blood Glucose
(drug effects, metabolism)
- Carbohydrates
(blood)
- Case-Control Studies
- Contraceptives, Oral
(administration & dosage, pharmacology)
- Contraceptives, Oral, Combined
(administration & dosage, pharmacology)
- Contraceptives, Oral, Hormonal
(administration & dosage, pharmacology)
- Dose-Response Relationship, Drug
- Estrogens
(administration & dosage)
- Ethinyl Estradiol
(administration & dosage, pharmacology)
- Female
- Glucose Tolerance Test
- Gonadal Steroid Hormones
(blood)
- Humans
- Insulin
(blood)
- Lipid Metabolism
(drug effects)
- Lipids
(blood)
- Norgestrel
(administration & dosage, analogs & derivatives, pharmacology)
- Polycystic Ovary Syndrome
(drug therapy, metabolism, physiopathology)
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