Tumor-Targeting Salmonella typhimurium A1-R: An Overview.

Abstract

The present chapter reviews the development of the tumor-targeting amino-acid auxotrophic strain S. typhimurium A1 and the in vivo selection and characterization of the high-tumor-targeting strain S. typhimurium A1-R. Efficacy of S. typhimurium A1-R in nude-mouse models of prostate, breast, pancreatic, and ovarian cancer, as well as sarcoma and glioma in orthotopic mouse models is described. Also reviewed is efficacy of S. typhimurium A1-R targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma, breast-cancer brain metastasis, and experimental breast-cancer bone metastasis in orthotopic mouse models. The efficacy of S. typhimurium A1-R on pancreatic cancer stem cells, on pancreatic cancer in combination with anti-angiogenic agents, as well as on cervical cancer, soft-tissue sarcoma, and pancreatic cancer patient-derived orthotopic xenograft (PDOX) mouse models, is also described.

• Authors: Robert M Hoffman
• Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 1409 Pg. 1-8 ( 2016) ISSN: 1940-6029 [Electronic] United States
• PMID: 26846797 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Nitric Oxide
• Nitroglycerin

Topics

• Amino Acids (metabolism)
• Animals
• Disease Models, Animal
• Humans
• Mice
• Neoplasms (metabolism, pathology, therapy)
• Nitric Oxide (metabolism)
• Nitroglycerin (metabolism)
• Permeability
• Salmonella typhimurium (classification, genetics, metabolism)
• Xenograft Model Antitumor Assays