Abstract | BACKGROUND: PATIENTS AND METHODS: RESULTS: Patients with a high expression of p21 (≥10%), p27 (>50%), Ki-67 (>50%), CD31 (>130 vessels/mm2) and low expression of p53 (<10%), cyclin D1 (<10%) and EGFR (<10%) (favorable levels - FL) had better DFS than patients with a low expression of p21 (<10%), p27 (≤50%), Ki-67 (≤50%), CD31 (<130 vessels/mm2) and high expression of p53 (≥10%), cyclin D1 (≥10%) and EGFR (≥10%) (unfavorable levels - UL). However, statistical significance in survival between FL and UL was achieved only for p27 and cyclin D1. DFS significantly decreased with an increasing number of markers with an unfavorable level per tumor (1-4 vs. 5-7) (78% vs. 32%, respectively; p = 0.004). The number of markers per tumor with UL of expression retained prognostic significance also in multivariate analysis. CONCLUSIONS: Statistical significance in survival between FL and UL emerged only for p27 and cyclin D1. The number of markers per tumor with UL of expression was an independent prognostic factor for an adverse outcome.
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Authors | Erika Soba, Marjan Budihna, Lojze Smid, Nina Gale, Hotimir Lesnicar, Branko Zakotnik, Primoz Strojan |
Journal | Radiology and oncology
(Radiol Oncol)
Vol. 49
Issue 4
Pg. 365-70
(Dec 2015)
ISSN: 1318-2099 [Print] Poland |
PMID | 26834523
(Publication Type: Journal Article)
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