Validity of new methods to evaluate renal function in cancer patients treated with cisplatin.

Abstract

PURPOSE:

Creatinine clearance (Ccr) is used as a marker of renal function in cancer chemotherapy, but it is not correlated with glomerular filtration rate (GFR) after high-dose cisplatin treatment. In addition to Ccr, measured using 24-h urine collection (24-h Ccr) or Cockcroft-Gault formula (CGF), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and the Japanese GFR estimation equation (the Japanese equation) have been recently developed to estimate GFR for predicting renal function. However, these equations remain to be evaluated, particularly in cancer patients treated with cisplatin. Therefore, we investigated the validity of these equations for predicting the GFR in cancer patients treated with cisplatin.

METHODS:

GFR was measured by inulin clearance (Cin) in 50 cancer patients and compared with GFR estimated by the CKD-EPI equation, the Japanese equation, and Ccr estimated by CGF or measured by 24-h Ccr before the first and third cisplatin-containing chemotherapy cycles (considered pretreatment and posttreatment, respectively).

RESULTS:

Before treatment, the CKD-EPI and the Japanese equations estimated GFR with higher accuracy than Ccr. Posttreatment bias values for GFR estimation using the CKD-EPI and the Japanese equations were lower than those for Ccr. The CKD-EPI and the Japanese equations were also more precise than Ccr. However, for patients with low renal function, these equations still overestimated Cin.

CONCLUSION:

The CKD-EPI and the Japanese equations estimated GFR with lower bias and higher precision than Ccr pre- and postcisplatin treatment. This study is registered at UMIN: 000002167.

• Authors: Yohei Funakoshi, Yutaka Fujiwara, Naomi Kiyota, Toru Mukohara, Takanobu Shimada, Masanori Toyoda, Yoshinori Imamura, Naoko Chayahara, Hideo Tomioka, Michio Umezu, Naoki Otsuki, Ken-ichi Nibu, Hironobu Minami
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 77 Issue 2 Pg. 281-8 (Feb 2016) ISSN: 1432-0843 [Electronic] Germany
• PMID: 26791871 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Biomarkers
• Inulin
• Creatinine
• Cisplatin

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents (administration & dosage, adverse effects, pharmacokinetics)
• Biomarkers (blood)
• Cisplatin (administration & dosage, adverse effects, pharmacokinetics)
• Creatinine (blood)
• Dose-Response Relationship, Drug
• Glomerular Filtration Rate (drug effects)
• Humans
• Inulin (blood)
• Japan
• Kidney Function Tests (methods)
• Metabolic Clearance Rate (drug effects)
• Middle Aged
• Neoplasms (drug therapy)
• Renal Elimination (drug effects)
• Renal Insufficiency (chemically induced, diagnosis)
• Reproducibility of Results