Evolving Strategies in the Treatment of Tuberous Sclerosis Complex-associated Angiomyolipomas (TSC-AML).

Abstract

Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder characterized by the development of numerous benign tumors that occur in multiple organ systems throughout the lifetime of the affected individuals. Renal angiomyolipomas occur in up to 80% of TSC patients, and chronic kidney disease from increasing tumor burden is the primary cause of TSC-related mortality. Our review evaluates evidence for localized and systemic therapy in the management of TSC-angiomyolipomas. Urologists or nephrologists experienced in TSC disease should coordinate the care of TSC patients with renal involvement to improve care and reduce costs.

• Authors: Anil Kapoor, Louis Girard, Jean-Baptiste Lattouf, York Pei, Ricardo Rendon, Paul Card, Alan So
• Journal: Urology (Urology) Vol. 89 Pg. 19-26 (Mar 2016) ISSN: 1527-9995 [Electronic] United States
• PMID: 26723178 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Topics

• Angiomyolipoma (therapy)
• Asymptomatic Diseases
• Decision Trees
• Humans
• Neoplasms, Multiple Primary (therapy)
• Practice Guidelines as Topic
• Tuberous Sclerosis