Histological changes caused by meclofenamic acid in androgen-independent prostate cancer tumors: evaluation in a mouse model.

Abstract

Meclofenamic acid is a nonsteroidal anti-inflammatory drug that has shown therapeutic potential for different types of cancers, including androgen-independent prostate neoplasms. The antitumor effect of diverse nonsteroidal anti-inflammatory drugs has been shown to be accompanied by histological and molecular changes that are responsible for this beneficial effect. The objective of the present work was to analyze the histological changes caused by meclofenamic acid in androgen-independent prostate cancer. Tumors were created in a nude mouse model using PC3 cancerous human cells. Meclofenamic acid (10 mg/kg/day; experimental group, n=5) or saline solution (control group, n=5) was administered intraperitoneally for twenty days. Histological analysis was then carried out on the tumors, describing changes in the cellular architecture, fibrosis, and quantification of cellular proliferation and tumor vasculature. Meclofenamic acid causes histological changes that indicate less tumor aggression (less hypercellularity, fewer atypical mitoses, and fewer nuclear polymorphisms), an increase in fibrosis, and reduced cellular proliferation and tumor vascularity. Further studies are needed to evaluate the molecular changes that cause the beneficial and therapeutic effects of meclofenamic acid in androgen-independent prostate cancer.

• Authors: Iván Delgado-Enciso, Alejandro D Soriano-Hernández, Alejandrina Rodriguez-Hernandez, Héctor R Galvan-Salazar, Daniel A Montes-Galindo, Rafael Martinez-Martinez, Laura L Valdez-Velazquez, Rafael Gonzalez-Alvarez, Francisco Espinoza-Gómez, Oscar A Newton-Sanchez, Agustín Lara-Esqueda, Jose Guzman-Esquivel
• Journal: International braz j urol : official journal of the Brazilian Society of Urology (Int Braz J Urol) 2015 Sep-Oct Vol. 41 Issue 5 Pg. 1002-7 ISSN: 1677-6119 [Electronic] Brazil
• PMID: 26689527 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Cyclooxygenase Inhibitors
• Meclofenamic Acid

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cyclooxygenase Inhibitors (pharmacology)
• Disease Models, Animal
• Fibrosis
• Humans
• Immunohistochemistry
• Male
• Meclofenamic Acid (pharmacology)
• Mice, Nude
• Neoplasm Invasiveness
• Neovascularization, Pathologic (drug therapy)
• Prostate (drug effects, pathology)
• Prostatic Neoplasms, Castration-Resistant (chemistry, drug therapy, pathology)
• Reproducibility of Results