Retrospective analysis of parkinsonian patients exhibiting normal (123)I-MIBG cardiac uptake.

Abstract

BACKGROUND:

Although most patients with Parkinson's disease (PD) show decreased cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake, some exhibit normal uptake. We evaluated the clinical characteristics of such patients.

METHODS:

We enrolled 154 non-demented patients showing parkinsonism with normal cardiac MIBG uptake and had been clinically followed up during 29.9 ± 27.6 months. We defined the patients who did not fit the exclusion criteria for PD and demonstrated ≥ 30% reduction in the Unified Parkinson's Disease Rating Scale (UPDRS) motor score after anti-Parkinson agent administration as probable PD. We compared clinical characteristics and the cardiac MIBG heart-to-mediastinum (H/M) ratio between the probable PD group (N=37) and other groups (N=117).

RESULTS:

The probable PD group showed significantly higher UPDRS motor scores and greater incidence of tremor/rigidity than those of other groups. In addition, they showed a significantly lower cardiac MIBG H/M ratio in the delayed phase (delayed, p<0.0001). Washout-rate (WR) was significantly higher in probable PD cases (p<0.0001). Among 16 probable PD patients undergoing serial cardiac MIBG scintigraphy, the delayed phase cardiac MIBG H/M ratio showed a significant decrease and WR significantly increased during follow-up periods.

CONCLUSIONS:

An increase in WR and lower delayed phase cardiac MIBG uptake were found to be characteristics of such patients.

• Authors: Yasuaki Mizutani, Shinji Ito, Kenichiro Murate, Seiko Hirota, Takao Fukui, Chika Hikichi, Tomomasa Ishikawa, Sayuri Shima, Akihiro Ueda, Madoka Kizawa, Kunihiko Asakura, Tatsuro Mutoh
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 359 Issue 1-2 Pg. 236-40 (Dec 15 2015) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 26671120 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Enzyme Inhibitors
• Iodine Radioisotopes
• 3-Iodobenzylguanidine

Topics

• 3-Iodobenzylguanidine (pharmacokinetics)
• Adult
• Aged
• Aged, 80 and over
• Enzyme Inhibitors (pharmacokinetics)
• Female
• Heart (diagnostic imaging, drug effects)
• Humans
• Iodine Radioisotopes (pharmacokinetics)
• Male
• Middle Aged
• Parkinsonian Disorders (diagnostic imaging, physiopathology)
• ROC Curve
• Radionuclide Imaging
• Retrospective Studies
• Severity of Illness Index