Alternate-day Treatment with Crizotinib for Drug-induced Esophagitis and Liver Damage in a Patient with EML4-ALK Fusion Gene-positive Lung Adenocarcinoma.

Abstract	A 44-year-old woman who was diagnosed with anaplastic lymphoma kinase-positive lung adenocarcinoma developed brain metastases, multiple spinal metastases and meningeal dissemination. Crizotinib was administered after the failure of first-line chemotherapy. Esophagitis and liver damage were induced by the twice-daily administration of crizotinib at 250 mg and 200 mg, respectively. The alternate-day administration of crizotinib (250 mg, twice daily) was able to control disease progression without any adverse effects for several months. We evaluated the relationship between the serum concentration of crizotinib and the development of esophagitis and liver damage. The alternate-day administration of crizotinib is one of the strategies for managing the severe toxicity of crizotinib.
Authors	Yoko Tsukita, Tatsuro Fukuhara, Maki Kobayashi, Mami Morita, Aya Suzuki, Kana Watanabe, Tetsuya Noguchi, Yasuko Kurata, Manabu Suno, Makoto Maemondo
Journal	Internal medicine (Tokyo, Japan) (Intern Med) Vol. 54 Issue 24 Pg. 3185-8 ( 2015) ISSN: 1349-7235 [Electronic] Japan
PMID	26666609 (Publication Type: Case Reports, Journal Article)
Chemical References	Protein Kinase Inhibitors Pyrazoles Pyridines Crizotinib ALK protein, human Anaplastic Lymphoma Kinase Receptor Protein-Tyrosine Kinases
Topics	Adenocarcinoma (drug therapy, pathology) Adenocarcinoma of Lung Adult Anaplastic Lymphoma Kinase Chemical and Drug Induced Liver Injury Crizotinib Drug Administration Schedule Esophagitis (chemically induced) Female Humans Lung Neoplasms (drug therapy, pathology) Neoplasm Metastasis Protein Kinase Inhibitors (administration & dosage, adverse effects, therapeutic use) Pyrazoles (administration & dosage, adverse effects, therapeutic use) Pyridines (administration & dosage, adverse effects, therapeutic use) Receptor Protein-Tyrosine Kinases (genetics) Treatment Outcome

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