Abstract | OBJECTIVES: METHODS: RESULTS: Micturition interval and micturition volume were significantly decreased and the frequency of micturition and basal pressure were significantly increased in the CYP-treated rats compared with sham-operated rats. Orally administered SPE significantly increased the micturition interval and micturition volume and decreased the frequency of micturition and basal pressure. The maximal number of sites (Bmax ) for the specific binding of [(3) H]NMS and [(3) H]αβ-MeATP was significantly decreased in the bladder. The decrease in receptors was attenuated by repeated treatment with SPE. An elevation in urinary cytokine (IL-1β and IL-17) levels were seen, and this increase was effectively suppressed by SPE treatment. CONCLUSIONS:
Saw palmetto extract attenuates the alteration of urodynamic parameters, pharmacologically relevant receptors, and urinary cytokines in CYP-treated rats. Therefore, SPE may be a potential therapeutic agent for improving the clinical symptoms of cystitis.
|
Authors | Sweety Nasrin, Eiji Masuda, Haruna Kugaya, Ayaka Osano, Yoshihiko Ito, Shizuo Yamada |
Journal | Lower urinary tract symptoms
(Low Urin Tract Symptoms)
Vol. 6
Issue 1
Pg. 57-63
(Jan 2014)
ISSN: 1757-5672 [Electronic] Australia |
PMID | 26663502
(Publication Type: Journal Article)
|
Copyright | © 2013 Wiley Publishing Asia Pty Ltd. |