[Double-blind controlled study of the efficacy of nifuroxazide versus placebo in the treatment of acute diarrhea in adults].

Abstract

In a double-blind, controlled randomized trial, 88 adult patients with acute diarrhea (more than three watery stools per day) received either 400 mg of nifuroxazide twice daily or placebo for 5 days. The mean duration of diarrhea in the nifuroxazide group was 2.09 days versus 3.26 days in the placebo group (p less than 0.004). The number of bowel movements per day diminished and mucus disappeared more quickly in patients treated by nifuroxazide than in patients of the placebo group. Nifuroxazide was well tolerated and no side effects were observed. Nifuroxazide is an effective therapy for acute diarrhea and can be prescribed from the onset of diarrhea without waiting for stool culture results which can be late or negative.

• Authors: P Bourée, J C Chaput, F Krainik, H Michel, C Trépo
• Journal: Gastroenterologie clinique et biologique (Gastroenterol Clin Biol) Vol. 13 Issue 5 Pg. 469-72 (May 1989) ISSN: 0399-8320 [Print] France
• Vernacular Title: Etude contrôlée en double aveugle de l'efficacité du nifuroxazide versus placebo dans le traitement de la diarrhée aiguë de l'adulte.
• PMID: 2666238 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Anti-Infective Agents
• Hydroxybenzoates
• Nitrofurans
• nifuroxazide

Topics

• Acute Disease
• Adult
• Anti-Infective Agents (therapeutic use)
• Diarrhea (drug therapy)
• Double-Blind Method
• Female
• France
• Humans
• Hydroxybenzoates (therapeutic use)
• Male
• Multicenter Studies as Topic
• Nitrofurans (therapeutic use)