[Association between CCND1 G870A polymorphism and radiotherapy response in high-risk human papillomavirus-related cervical cancer].

Abstract

OBJECTIVE:

To investigate the correlation of cyclin D1 (CCND1) G870A single nucleotide polymorphism (SNP) with radiotherapy response in patients with high risk human papillomavirus (HR-HPV) related cervical cancer.


METHODS:

A total of 273 patients with cervical cancer, who were confirmed by histopathology and hybrid capture 2 (HC-2) assay and treated by radiotherapy, were enrolled for this study. The correlation of CCND1 G870A polymorphism with tumor response in patients was assessed.


RESULTS:

Compared with patients with AA genotype, the patients with GG genotype and AA genotype showed lower sensitivity to radio-therapy treatment (adjusted ORGA=2.69, 95% CI 1.28-5.67 and adjusted ORGG=3.28, 95% CI 1.47-7.29, respectively), an increase in risks of recurrence/metastasis (adjusted ORGA=2.52, 95% CI 1.12-5.63 and adjusted ORGG=3.95, 95% CI 1.68-9.26, respectively), and shorter recurrence/metastasis-free survival (PGA=0.010 and PGG=0.045).


CONCLUSION:

G870A polymorphism is a frequent variation that could be used for evaluate the radio-sensitivity and prognosis for patients with HR-HPV related cervical cancer.

• Authors: Shaoqiang Liang, Ning Zhang, Rong Huang, Jun Jiang, Lusi Chen, Zhiqian Lu, Shaoen Li
• Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 40 Issue 11 Pg. 1205-9 (Nov 2015) ISSN: 1672-7347 [Print] China
• PMID: 26643423 (Publication Type: Journal Article)

Chemical References

• CCND1 protein, human
• Cyclin D1

Topics

• Cyclin D1 (genetics)
• Female
• Genotype
• Humans
• Papillomaviridae
• Polymorphism, Single Nucleotide
• Prognosis
• Uterine Cervical Neoplasms (genetics, radiotherapy, virology)