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Scanning proton beam therapy reduces normal tissue exposure in pelvic radiotherapy for anal cancer.

Abstract
An inter-comparison planning study between photon beam therapy (IMRT) and scanning proton beam therapy (SPBT) for squamous cell carcinoma of the anus (SCCA) is presented. SPBT plans offer significant reduction (>50%, P=0.008) in doses to small bowel, and bone marrow thereby offering the potential to reduce bowel and hemotoxicities.
AuthorsAman Anand, Martin Bues, William G Rule, Sameer R Keole, Chris J Beltran, Jun Yin, Michael G Haddock, Christopher L Hallemeier, Robert C Miller, Jonathan B Ashman
JournalRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Radiother Oncol) Vol. 117 Issue 3 Pg. 505-8 (Dec 2015) ISSN: 1879-0887 [Electronic] Ireland
PMID26597231 (Publication Type: Journal Article)
CopyrightCopyright © 2015 Elsevier Ireland Ltd. All rights reserved.
Topics
  • Aged
  • Anus Neoplasms (radiotherapy)
  • Bone Marrow (radiation effects)
  • Carcinoma, Squamous Cell (radiotherapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pelvis (radiation effects)
  • Proton Therapy
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy, Intensity-Modulated

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