Is there a best TKI for chronic phase CML?

Abstract

The development of BCR/ABL1 tyrosine kinase inhibitors (TKIs) over the past 20 years has dramatically improved the outcomes for patients with every stage of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML). Clinicians now have access to 5 oral, generally well-tolerated, and highly effective TKIs. How should these agents be used for an individual patient to ensure the best possible duration and quality-of-life, to avoid treatment-related complications, and potentially to achieve a cure at an affordable cost? Because CML patients may need to continue TKI therapy indefinitely, the long-term safety of each treatment option must be considered. Evidence-based care requires an understanding of the optimal use of these drugs, their specific early and late toxicities, the prognostic significance of achieving treatment milestones, and the critical importance of molecular monitoring. Efficacy is important, but treatment choice does not depend only on efficacy. Choosing among various treatment options is informed by understanding the distinct benefits and risks of each agent, along with careful consideration of patient-specific factors, such as risk status, age, and comorbidities.

• Authors: Richard A Larson
• Journal: Blood (Blood) Vol. 126 Issue 21 Pg. 2370-5 (Nov 19 2015) ISSN: 1528-0020 [Electronic] United States
• PMID: 26585806 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2015 by The American Society of Hematology. All rights reserved.

Chemical References

• BCR-ABL1 fusion protein, human
• Protein Kinase Inhibitors
• Fusion Proteins, bcr-abl

Topics

• Animals
• Fusion Proteins, bcr-abl (antagonists & inhibitors, genetics, metabolism)
• Humans
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (drug therapy, enzymology, genetics, pathology)
• Philadelphia Chromosome
• Protein Kinase Inhibitors (therapeutic use)